What does the absence of a medically actionable finding in any of the ACMG 59 genes mean?

Medically actionable findings are findings in specific “medically actionable” genes. These genes are related to health conditions with known medical recommendations for health care providers to act upon (“actionable”) with their patients. The American College of Genetics and Genomics (ACMG) recommends that findings in 59 medically actionable genes be reported to patients and individuals since medical care decisions can be made based upon these findings. Many of these genes are related to inherited forms of cancer and heart conditions. If you choose to learn about medically actionable findings and your research DNA data did not show a medically actionable finding, this would reduce the chance that you have an inherited health risk related to the ACMG 59 genes. But it would not eliminate the possibility. This is because the testing currently cannot pick up all types of disease-causing variants in the 59 genes reviewed. Additionally, your gGAP data is research data; unlike medical tests typically ordered by your doctor, research data is not intended for diagnosing medical conditions with the same level of accuracy. If you have a personal or family history of a medical condition that is (or could be) genetic, you should not rely on testing of your gGap data for medical information. In that case, there may be different genetic testing that would be better for you to consider having, which you can discuss with your doctor or certified genetic counselor. View More