You’re interested in sponsored genetic testing with Arrowhead Pharmaceuticals. We’re here to help!

Genome Medical has teamed up with Arrowhead Pharmaceuticals and Ambry Genetics to provide a sponsored, no-cost genetic testing program for patients who have a clinical history of severe hypertriglyceridemia. Patients who are eligible for this program may have an underlying genetic cause of their complications, such as Familial Chylomicronemia Syndrome or hyperlipoproteinemia.

Program Eligibility

Ambry Genetics’ HTG-Select panel is a 6-gene test aimed at identifying the underlying genetic cause of hypertriglyceridemia in eligible patients. This includes disorders such as Familial Chylomicronemia Syndrome (FCS) or other clinically associated conditions. This program is available to individuals with all the following:

  • 17 years of age and older
  • Fasting triglyceride level of >750 mg/dL [> 8.48 mmol/L] in the past 12 months
  • No Prior genetic testing for FCS

Note: The registration process will ask about Medicare coverage. Medicare will not be billed and both the genetic counseling visit and testing are 100% covered. Patients that elect to participate in this program will not be financially responsible.

Get Started Today

With Genome Medical, you can register and schedule your consultation with a certified genetic counselor online and attend from the comfort of your own home

Schedule Now
APPLICABLE TO US RESIDENTS ONLY

You’re interested in sponsored genetic testing with Arrowhead Pharmaceuticals. We’re here to help!

Genome Medical has teamed up with Arrowhead Pharmaceuticals and Ambry Genetics to provide a sponsored, no-cost genetic testing program for patients who have a clinical history of severe hypertriglyceridemia. Patients who are eligible for this program may have an underlying genetic cause of their complications, such as Familial Chylomicronemia Syndrome or hyperlipoproteinemia.

Program Eligibility

Ambry Genetics’ HTG-Select panel is a 6-gene test aimed at identifying the underlying genetic cause of hypertriglyceridemia in eligible patients. This includes disorders such as Familial Chylomicronemia Syndrome (FCS) or other clinically associated conditions. This program is available to individuals with all the following:

  • 17 years of age and older
  • Fasting triglyceride level of >750 mg/dL
    [> 8.48 mmol/L] in the past 12 months
  • No Prior genetic testing for FCS


Note: The registration process will ask about Medicare coverage. Medicare will not be billed and both the genetic counseling visit and testing are 100% covered. Patients that elect to participate in this program will not be financially responsible.

Get Started Today

With Genome Medical, you can register and schedule your consultation with a certified genetic counselor online and attend from the comfort of your own home

Schedule Now
APPLICABLE TO US RESIDENTS ONLY

How It Works

How It Works

What to Expect from a
Pre-Test Consultation

Initial consultation icon

Pre-test consultation

Talk with an expert by phone or video at no cost before your test is ordered. We review your personal and family health history, answer any questions you may have, and confirm that you meet eligibility criteria for Arrowhead Pharmaceuticals sponsored testing program.

Genetic testing icon

Easy ordering

If you meet the criteria for the program, then your no-charge Ambry HTG-Select test order will be placed by one of our physicians at no cost. We will also coordinate the convenient collection of a DNA sample — usually through a saliva kit that is sent directly to you.

Testing at home

After the saliva testing kit arrives, complete the test kit instructions and provide a saliva sample. Mail the test kit back in the pre-paid envelope. Results will be ready in 2-4 weeks. Learn more about How Genetic Testing works with Ambry Genetics.

Results review icon

Results consultation

Review your test results with a genetic counselor or medical geneticist free of charge. During this phone or video session, you can discuss the results of your test and their implications. You will receive a written summary and guidance on any actionable insights, including how your physician can integrate the results into your medical care.

Integration icon

Ongoing care

Our genetic counselors can offer personalized insights, clinical action plans and referrals to specialists as needed.

What to Expect from a
Pre-Test Consultation

Initial consultation icon

Pre-test consultation

Talk with an expert by phone or video at no cost before your test is ordered. We review your personal and family health history, answer any questions you may have, and confirm that you meet eligibility criteria for Arrowhead Pharmaceuticals sponsored testing program.

Genetic testing icon

Easy ordering

If you meet the criteria for the program, then your no-charge Ambry HTG-Select test order will be placed by one of our physicians at no cost. We will also coordinate the convenient collection of a DNA sample — usually through a saliva kit that is sent directly to you.

Testing at home

After the saliva testing kit arrives, complete the test kit instructions and provide a saliva sample. Mail the test kit back in the pre-paid envelope. Results will be ready in 2-4 weeks. Learn more about How Genetic Testing works with Ambry Genetics.

Results review icon

Results consultation

Review your test results with a genetic counselor or medical geneticist free of charge. During this phone or video session, you can discuss the results of your test and their implications. You will receive a written summary and guidance on any actionable insights, including how your physician can integrate the results into your medical care.

Integration icon

Ongoing care

Our genetic counselors can offer personalized insights, clinical action plans and referrals to specialists as needed.

Frequently Asked Questions

Who is Ambry Genetics?

Ambry is committed to advancing science by continually optimizing our methodology of detecting variants in order to bring you the most comprehensive test results possible.

Who is Arrowhead Pharmaceuticals?

Arrowhead Pharmaceuticals is researching medicines to determine whether they can effectively treat intractable diseases by silencing the genes that cause them. Arrowhead investigational therapies are being tested to determine whether they can effectively treat FCS patients.

Who is Genome Medical?

Genome Medical is the first nationwide specialty medical practice that is focused on genetics. The Genome Medical team features top genetics experts and primary care MDs – all dedicated to helping accelerate the integration of genetics into everyday health care.

How will my privacy be protected?

The results stored in your health record are protected by a health information privacy law known as Health Information Portability and Accountability Act (HIPAA) and the Genetic Information Nondiscrimination Act (GINA) protects patients from genetic discrimination.

What is genetic testing? DNA 101

To learn about DNA, it helps to start with our genes. We inherit our genes from our parents. Genes contain instructions for all of our traits – such as hair color, eye color, aspects of our health – many things that make us who we are. Although we can’t see them, genes are in the millions of cells throughout our bodies. Genes are found in structures called chromosomes, which are also in our cells.

Genes are made up of chemical building blocks called DNA, abbreviated as “A,” “C,” “T” and “G,” which are spelled in a very specific order to make up a gene. Since genes have instructions for our health, small changes in the way our DNA is spelled in a gene – like a typo – can impact our health. These small changes are called DNA variants.

One type of genetic testing is called DNA sequencing, which studies the DNA within our genes to look for DNA variants. Some DNA variants cause minor traits in us, like the color of our eyes. Other DNA variants can impact our health, such as DNA variants that cause us to have an increased risk for cancer.

Genetic testing looks for DNA variants to figure out a genetic cause or risk for health problems. Knowing if you have a genetic health risk can help you and your doctors plan for any medical checks or tests you should have to maintain your health, and also about any health risks to your family members.

What is a genetic counselor?

A genetic counselor is a genetic expert that can help you understand how genetics impacts your health, whether genetic testing is right for you and what tests might be the most appropriate. A genetic counselor is specially trained to understand the complexities of genetic tests and how to interpret an individual’s unique results.

What are the qualifications of the genetic experts at Genome Medical, and why should I consult with one?

Genome Medical’s national network of genetic experts includes both medical geneticists and genetic counselors. Your consultation will most likely be with a genetic counselor, who is a medical provider specially trained to understand the complexities of genetic tests and how to interpret an individual’s unique results. In certain cases, you may also work with a medical geneticist, a physician trained in general medicine, genetic diagnosis and the treatment of patients with genetic disorders. Genetic counselors start by learning what important health questions you have, assessing your risk for disorders of interest and then reviewing how genetic testing may help you answer them. Their recommendations are tailored to address the issues that are most important to you. If you have questions about your results, genetic counselors are there to explain what it means and work with you to understand best next steps and develop a care plan. You can learn more about genetic counselors here.

What can I learn/what are the limitations of the genetic test conducted by Ambry?

Genetic testing is the process of examining our genetic makeup to detect disease-causing mutations. Ambry’s HTG-Select test is a 6-gene panel that analyzes genes associated with FCS. The test can be an effective way of identifying at-risk individuals or clarifying risks to family members, however, genetic testing cannot predict onset or severity of disease.

What is HTG-Select?

Ambry Genetics’ HTG-Select panel is a 6-gene test aimed at identifying the underlying genetic cause of hypertriglyceridemia in eligible patients. This includes disorders such as Familial Chylomicronemia Syndrome or other clinically associated conditions. Genes included are associated with one or more key clinical symptoms, including: severely high triglyceride levels, acute bouts of pancreatitis, severe abdominal pain, skin xanthomas, memory loss, and milky appearance of the blood/veins.

Establishing an underlying molecular cause is a critical step in providing accurate diagnosis, prognosis, genetic counseling, and disease management.

What is Familial Chylomicronemia Syndrome (FCS)?

Familial chylomicronemia syndrome (FCS) is a severe and ultra rare genetic disease, with a prevalence of approximately 1 in 1,000,000. Patients with FCS are unable to effectively breakdown dietary fats resulting in severe elevations in triglycerides in the blood, which can cause serious signs and symptoms including acute pancreatitis (which can be fatal), chronic daily abdominal pain, type 2 diabetes mellitus, hepatic steatosis, and cognitive issues (aka “brain fog”). FCS is often controlled by severely limiting dietary fat intake, which can reduce the risk of pancreatitis. Pancreatitis is a major life-threatening complication of FCS and can lead to other life-threatening conditions such as sepsis, acute respiratory distress syndrome, hypovolemic shock, and renal failure.

Additional resources for learning more about Familial Chylomicronemia Syndrome:

Why is Arrowhead sponsoring no-cost testing for eligible patients?

As an RNAi focused pharmaceutical company, Arrowhead understands the important role genes can play in rare diseases such as hypertriglyceridemia and FCS. Accessing confidential, trusted, affordable, and timely genetic testing and counseling services can be a challenge for patients and providers for a variety of reasons. By providing no-cost genetic testing, Arrowhead hopes to further demonstrate its ongoing commitment to engagement with the FCS patient and caregiver communities as studies continue to find effective treatments and broaden awareness of this rare, but impactful disease.

Why does the registration ask me if I have Medicare coverage?

The Medicare coverage question is currently required as part of the registration process. If a participant selects they are covered by Medicare, they will be required to complete an ABN form. Medicare will not be billed and both the genetic counseling visit and testing are 100% covered. Patients that elect to participate in this program will not be financially responsible.

How can I prepare for my consultation?

Prior to your scheduled consultation, it would be helpful to think about your reasons for pursuing testing, and if you have any concerns regarding your family history that you were hoping to address. Please attempt to find out as much information as you can about your family history before the appointment and share that information with your genetic counselor.

What should I expect during the pre-test consultation?

During your pre-test consultation you will meet with a Genome Medical board certified genetic counselor via phone. Your genetic counselor will:

  • Answer any important health questions you may have
  • Collect your personal and family health history
  • Review any genetic testing that has been ordered or performed
  • Assess your risk for a variety of inherited conditions

How long will it take to schedule an appointment with a genetic expert?

You can schedule a telehealth appointment at your convenience, generally within 1-2 business days. Please make sure to leave yourself enough time to complete the medical questionnaire before your appointment.

What is the value of genetic consultation?

The goals of a genetic consultation are to assess your risk for genetic condition and to help guide you in making an informed choice about genetic testing.

What happens if results come back negative?

If results are negative, we will send you a letter, a clinical action plan (CAP), detailing your results. A genetic consultation is available if you have questions regarding any of the test results.

How long after I give my sample will my results be available?

In most cases, test results will be available in approximately 2-4 weeks.

What information is included in my summary results report?

A clinical action plan (CAP), is provided to you once results are complete. The CAP is a written summary of the results and guidance on any actionable insights, including how you and your family’s physician can integrate results into medical care.

How do I receive my results report?

Genome Medical will contact you via email or phone once your results are ready. At that time, it is encouraged that you schedule a post-test consultation to review the results to better understand what the results mean for you and your family.

How should my own physician be involved?

We recommend sharing your clinical action plan (CAP) with your physician so that the physician can manage any recommendations regarding the results. Your physician can also contact Genome Medical if there are any questions regarding the recommendations or results.

From Trusted Experts

Arrowhead Pharmaceuticals Logo

No-cost testing

Arrowhead Pharmaceuticals is researching medicines to determine whether they can effectively treat intractable diseases by silencing the genes that cause them. Arrowhead investigational therapies are being tested to determine whether they can effectively treat FCS patients.

Genome Medical Logo

Expert genetic counseling

Provided by top genetic experts at Genome Medical, dedicated to helping accelerate the integration of genetics into everyday health care.

Ambry Genetics Logo

Clinical-grade testing

Ambry Genetics is a company built by scientists, genetic counselors, and healthcare providers who share an unwavering commitment to improving the lives of patients at risk for or suffering from inherited diseases.

From Trusted Experts

Arrowhead Pharmaceuticals Logo

No-cost testing

Arrowhead Pharmaceuticals is researching medicines to determine whether they can effectively treat intractable diseases by silencing the genes that cause them. Arrowhead investigational therapies are being tested to determine whether they can effectively treat FCS patients.

Genome Medical Logo

Expert genetic counseling

Provided by top genetic experts at Genome Medical, dedicated to helping accelerate the integration of genetics into everyday health care.

Ambry Genetics Logo

Clinical-grade testing

Ambry Genetics is a company built by scientists, genetic counselors, and healthcare providers who share an unwavering commitment to improving the lives of patients at risk for or suffering from inherited diseases.

More Questions? No Problem!

Do you want more clarification before committing to a consultation? We are here to help.

Chat icon

Connect live with a
Genome Medical
care coordinator.

Chat
Phone icon

Call (877) 688-0992
at a time convenient
for you.

Call
Envelope icon

Submit your question by email. Replies may take within 1-2 business days.

Email

More Questions? No Problem!

Do you want more clarification before committing to a consultation? We are here to help.

Chat icon

Connect live with a
Genome Medical
care coordinator.

Chat
Phone icon

Call (877) 688-0992
at a time convenient
for you.

Call
Envelope icon

Submit your question by email. Replies may take within 1-2 business days.

Email