The American College of Medical Genetics and Genomics (ACMG) currently recommends that disease-causing variants in 59 genes be reported to individuals, sometimes referred to as the ACMG 59. The ACMG selected these genes because they are “medically actionable” – related to health conditions with known medical recommendations for healthcare providers to act upon (“actionable”) with their patients. These 59 genes are mainly associated with inherited forms of cancer and heart conditions. If someone has a finding in one of the 59 genes, knowing this information can help reduce their risk associated with that specific condition (e.g. cancer or sudden cardiac death).
